3-amino-2-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-[3-(trifluoromethyl)phenyl]butanoic acid
Boc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid
CAS: 269726-74-1
Molecular Formula: C16H20F3NO4
3-amino-2-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-[3-(trifluoromethyl)phenyl]butanoic acid - Names and Identifiers
3-amino-2-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-[3-(trifluoromethyl)phenyl]butanoic acid - Physico-chemical Properties
| Molecular Formula | C16H20F3NO4 |
| Molar Mass | 347.33 |
| Storage Condition | 2-8°C |
3-amino-2-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-[3-(trifluoromethyl)phenyl]butanoic acid - Risk and Safety
| Hazard Class | IRRITANT |
3-amino-2-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-[3-(trifluoromethyl)phenyl]butanoic acid - Introduction
Boc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid is an important organic compound with the following properties:
1. Appearance: Colorless crystalline solid.
2. molecular formula: C17H20F3NO4.
3. Molecular weight: 365.34g/mol.
4. Solubility: Soluble in most organic solvents, such as dimethyl sulfoxide and dichloromethane.
5. melting point: about 144-148 ℃.
One of the main uses of Boc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid is as a pharmaceutical intermediate. It can be converted into an effective amino acid or peptide compound by removing the Boc protecting group (Boc deprotection), and thus used in the synthesis of drugs. In addition, it can also be used for other reactions in organic synthesis, such as coupling reactions and hydrogenation reactions.
A common method for preparing Boc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid is to react Boc-protected alanine with 3-trifluoromethylbenzoic acid. First, Boc-alanyl chloride is obtained by reacting alanine with an acylation reaction of acetone and an acid catalyst. Then, Boc-alanyl chloride is subjected to a condensation reaction with 3-trifluoromethylbenzoic acid to give Boc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid.
When using or handling Boc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid, you should pay attention to some safety information. It is an organic compound that may have some toxicity. Therefore, the operation should be carried out under appropriate laboratory conditions. Avoid inhalation, contact with skin and eyes. At the same time, pay attention to the use of personal protective equipment, such as laboratory gloves and laboratory glasses, to ensure safety. When disposing of waste, proper disposal should be carried out in accordance with local laws and regulations.
1. Appearance: Colorless crystalline solid.
2. molecular formula: C17H20F3NO4.
3. Molecular weight: 365.34g/mol.
4. Solubility: Soluble in most organic solvents, such as dimethyl sulfoxide and dichloromethane.
5. melting point: about 144-148 ℃.
One of the main uses of Boc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid is as a pharmaceutical intermediate. It can be converted into an effective amino acid or peptide compound by removing the Boc protecting group (Boc deprotection), and thus used in the synthesis of drugs. In addition, it can also be used for other reactions in organic synthesis, such as coupling reactions and hydrogenation reactions.
A common method for preparing Boc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid is to react Boc-protected alanine with 3-trifluoromethylbenzoic acid. First, Boc-alanyl chloride is obtained by reacting alanine with an acylation reaction of acetone and an acid catalyst. Then, Boc-alanyl chloride is subjected to a condensation reaction with 3-trifluoromethylbenzoic acid to give Boc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid.
When using or handling Boc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid, you should pay attention to some safety information. It is an organic compound that may have some toxicity. Therefore, the operation should be carried out under appropriate laboratory conditions. Avoid inhalation, contact with skin and eyes. At the same time, pay attention to the use of personal protective equipment, such as laboratory gloves and laboratory glasses, to ensure safety. When disposing of waste, proper disposal should be carried out in accordance with local laws and regulations.
Last Update：2024-04-09 21:11:58
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